Clinical proteomics

Enable clinical proteomics research

Obtain more precise, reliable date from your clinical proteomics research by stabilizing your samples

Superior sample preservation ensures the quality and validity of your analytical results
Diagnostics and analytics for personalized medicine will greatly benefit from a standardized approach to stabilize samples, as this enables a validated comparison in and between patient groups. Sample stability and reproducible sample preparation is a key element when analyzing clinical tissue using Mass spectrometry or MALDI MSI in the search for quickly degrading cancer biomarkers such as phosphorylated Met, Cas, pAKT, pStat, pERK, pp38, pHER2, p-S6K1 etc.

Heat stabilization is a revolutionary sample preservation technique that stops biological change immediately and permanently, without the use of additives. It enables accurate analysis and quantification of unstable protein biomarkers such as phosphorylations, endogenous peptides and small molecules. Using heat stabilization also reduces technical errors associated with sampling and allows you to compare true biological variation. In addition, the  heat stabilization approach also stabilizes and deactivates any microbiological and viral activity in tissue samples without loss of their molecular signatures. Learn more about heat stabilization

The Stabilizorâ„¢ system is a portable, benchtop instrument that can be used for all tissue types, fresh or frozen, allowing you to stabilize and secure currently biobanked samples.

* Preserves tissue biomarkers directly in the operating room
* Retains the molecular information from the moment of sampling throughout the entire analysis workflow
* Ensures quality and standardization of sample collection
* Enables both proteomic and genomic analyses

Recommended reading

Biomarkers of disease and post-mortem changes-heat stabilization, a necessary tool for measurement of protein regulation, Kultima et al., Journal of Proteomics, 2011.

Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization. Rountree et al, Proteome Sci. 2010, 8.

Application note

Enables detection of biomarkers in cancer research